CMA, also known as DNA chip or biochip, is a new method of fetal genetic testing that replaces the traditional karyotype test. Instead of using a microscope, which offers limited diagnostic possibilities, the DNA is placed on a chip and undergoes a computer scan. This way the chromosomes are examined in much greater detail and many syndromes, which remain undetected under the microscope, can be diagnosed.

Using the chip, many areas of the fetal genetic material can be examined simultaneously, with high-resolution results. Hundreds of syndromes can be identified including genetic Autistic Spectrum Disorders and retardation that previously could not be detected.

The biochip has another significant advantage - the scan of the genetic material is stored on the computer and can be accessed later on. This means that if further diagnosis or examination of the results is required, no additional invasive procedure will need to be performed.

Only a small number of medical centers in Israel offer this test. Shaare Zedek Medical Center embraced CMA from its inception physicians from all over the country come to Shaare Zedek to learn about it. 

CMA is approved by the Israeli Ministry of Health and is included in the healthcare basket for women with findings that indicate a possibility of fetal genetic disease. However, studies have found that even without unusual findings, some fetuses develop problems stemming from minute chromosomal changes that can only be detected using the chip. For this reason CMA is provided at Shaare Zedek, at no extra charge, to any woman who requests it.

Prior to the amniocentesis procedure and the chip test you will receive comprehensive genetic counseling. The geneticist will accompany you throughout the process and will provide a detailed explanation of the results. Results are usually received within 2-4 weeks after the genetic material is received at the lab for analysis.